Northen Bio

Trent R. Northen

Education

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Professional Experience

2009-Present           Berkeley Lab Carbon Cycle 2.0 steering committee

2008-Present           MetaCyc Scientific Advisory Board (Stanford Research International)

2008-present           Research Scientist, Life Sciences Division, Lawrence Berkeley National Lab

2006- 2008              The Scripps Research Institute Center for Mass Spectrometry under Prof. Gary Siuzdak

2001-2005               Graduate Research/Teaching Assistant under Prof. Neal Woodbury, Arizona State University

1996-2000               Scientist and Process Engineer, The Clorox Company

Honors

Presidential Early Career Award in Science and Engineering (Awarded 2010)

Awarded SPORE career development award (2009) & (2010)

Awarded “Innovator of Tomorrow”, Arizona State University (ASU)/AzTe (2006)

Outstanding Research Assistant, Chemistry and Biochemistry Department, ASU (2005)

Outstanding Teaching Assistant, Chemistry and Biochemistry Department, ASU (2003)

NSF IGERT fellowship (2001-2005)

Outstanding Chemical Engineering Student in graduating class (1996)

Elected into Tau Beta Pi – Engineering Honor Society (since 1995)

Selected Publications

2011

Bowen, Benjamin P; Baran, Richard; Northen, Trent R. Improved genome annotation through untargeted detection of pathway-specific metabolites. BMC Genomics (in press).

Wolfgang Reindl, Kai Deng, John M. Gladden, Gang Cheng, April Wong,  Steven W. Singer, Seema Singh,Jinq-Chyi Lee, Chun-Hsu Yao,Terry C. Hazen,Anup K. Singh, Blake A. Simmons, Paul D. Adams and Trent R. Northen. Colloid-based multiplexed screening for plant biomass-degrading glycoside hydrolase activities in microbial communities. Energy and Envir.Sci. (in press).

Baran, Richard, Bowen, Benjamin, Northen, Trent R. Untargeted metabolic footprinting reveals a surprising breadth of metabolite uptake and release by Synechococcus sp. PCC 7002. Molecular BioSystems (in press).

Reindl, Wolfgang E; Bowen, Benjamin, P; Balamontis, Michael A; Green, Jeffery, E; Northen, Trent R. Multivariate analysis of a 3D mass spectral image for examining tissue heterogeneity. Integrative Biology (2011), 3: 460-467.

2010

Reindl, Wolfgang; Northen, Trent. Rapid Screening of Fatty Acids Using Nanostructure-Initiator Mass Spectrometry. Analytical Chemistry (2010), 9, 3751-3755.

Bowen, Benjamin P., Northen, Trent. Dealing with the unknown: Metabolomics and Metabolite Atlases, JASMS (2010). 21(9):1471-1476.

Jansson, Christer, Northen, Trent. Calcifying cyanobacteria-the potential of biomineralization for carbon capture and storage. curr opin biotechnol (2010) 2010 Jun;21(3):365-71

Facciotti M.T., Pang W.L., Lo F-Y., Whitehead K., Koide T., Masumura K., Pan M., Kaur A., Larsen D.J., Reiss D.J., Hoang L., Kalisiak E., Northen T., Trauger S.A., Siuzdak G., Baliga N.S. Large scale physiological readjustment during growth enables rapid, comprehensive and inexpensive system analysis.  BMC Syst Biol (2010) 4:64

Lee, Do Yup, Bowen, Benjamin P, Northen, Trent R. Mass spectrometry based metabolomics, analysis of metabolite-protein interactions, and imaging. Biotechniques, (2010), 49(2): 557-65 (COVER).

Baran R, Bowen BP, Bouskill NJ, Brodie EL, Yannone SM, Northen TR. Metabolite Identification in Synechococcus sp. PCC 7002 Using Untargeted Stable Isotope Assisted Metabolite Profiling. Analytical Chemistry (2010)  82(21): 9034–9042

Wilmes, Paul ; Bowen, Benjamin P ; Thomas Brian C; Mueller Ryan S; Denef Vincent J; VerBerkmoes Nathan C; Hettich Robert L; Northen Trent R; and Banfield Jillian F. Metabolome-proteome differentiation coupled to microbial divergence. mBio (2010) 1 (5): 1-5.

2009

Woo, Hin-Koon; Go, Eden P; Hoang, Linh; Trauger, Sunia A.; Bowen, Benjamin; Siuzdak, Gary; Northen, Trent R.^. Phosphonium Labeling for Increasing Metabolomic Coverage of Neutral Lipids using ESI-MS. Rapid. Comm. Mass Spec. (2009) 23(12), 1849-55.

Yanes Oscar; Woo, Hin-Koon; Northen, Trent; Oppenheimer, Stacey; Schriver, Leah; Apon, Jon; Estrada, Myra; Potchoiba, Michael; Manchester, Marianne; Siuzdak, Gary. Nanostructure-Initiator Mass Spectrometry (NIMS) Tissue Imaging and Biofluid Analysis. Analytical Chemistry (2009), 81 (8), 2969-2975.

Baran, Richard; Reindl, Wolfgang; Northen, Trent. Mass Spectrometry Based Metabolomics and Enzymatic Assays for Functional Genomics. Current Op. in Microbiology (2009), 12, 547-552 COVER.

2008

Northen Trent R, Lee J-C, Hoang L., Raymond J., Hwang D-R, Yannone S.M., Wong C-H, Siuzdak G. A Nanostructure-Initiator Mass Spectrometry Based Enzyme Activity Assay, PNAS, (2008) 105(10), 3678-3683

Woo H-K., Northen T.R., Yanes O., Siuzdak G.  Nanostructure-Initiator Mass Spectrometry (NIMS): A protocol for preparing and applying NIMS surfaces for high sensitivity mass analysis. Nature Protocols 3, 1341-1349 (2008).

Nordström, Anders; Want Elizabeth; Northen, Trent ; Gieschen, Anderew; Fisher, Steven; Siuzdak, Gary. A Multiple Ionization Mass Spectrometry Strategy Used to Reveal the Complexity of Metabolomics.  Analytical Chemistry, (2008), 80, 421-429.

Northen T.R. Greving M., Woodbury N.W. Combinatorial Screening of Biomimetic Protein Affinity Materials. Advanced Materials (2008) 20, 1-7.

2007

Northen,  Trent R; Yanes, Oscar; Northen, Michael T; Marrinucci,  Dena C; Uritboonthai, Winnie; Apon, Junefredo ; Golledge, Stephen L; Nordström, Anders; Sizudak, Gary.  Clathrate Nanostructures for Mass Spectrometry. Nature (2007) 449, 1033-1036.

Northen, Trent R; Wu, Hin-Koon, Northen, Michael T; Nordström, Anders; Uritboonthai, Winnie; Turner, Kimberly L., Sizudak, Gary. High Surface Energy of Porous Silicon Drives Desorption of Intact Molecules. JASMS (2007) 18 (11), 1945-1949.

Patents:

Northen; Trent R. (Oakland, CA); Flagler; Robert W. (Pleasanton, CA); Ball; Alan D. (Somerville, MA); Schnakenberg, III; George H. F. (Cambridge, MA). Patent US D435,084.Water Filter (2000)

Flagler; Robert W. (Pleasanton, CA); Northen; Trent R. (Oakland, CA); Ball; Alan D. (Somerville, MA); Schnakenberg, III; George H. F. (Cambridge, MA). Patent US D437,027 Water filter reservoir (2001)

Northen; Trent R.(Oakland, CA); Patent WO0223989. Insecticidal Microcrystalline Dry Aerosol Spray (2002).

Northen; Trent, Russell (Tempe, Az); Woodbury; Neal, Walter. (Tempe, Az); Full Patent Application PCT/US05/15764, U.S. provisional applications 60/569,370, 60/608,774, and 60/623,181 (2004). Microarray of Three-Dimensional Heteropolymer Microstructures and Method Therefor (2005).

Northen; Trent, Russell (Tempe, Az); Greving; Matthew (Phoenix, Az), Woodbury; Neal, Walter. (Tempe, Az); Full patent  application Ser. No. 01231.0039P1 Microstructure and microdomain microarrays, methods and uses therefore (2006). U.S. provisional application Characterization and Synthesis of Three-Dimensional Heteropolymer Microstructure Arrays and Method Therefore  (2005)

Northen; Trent, Russell (San Diego, Ca); Nordström; Anders (La Jolla, Ca); Siuzdak; Gary (La Jolla, Ca); U.S. Patent application 11/852,863. Nanostructure-Initiator Mass Spectrometry (2007).

Matthew P. Greving, Neal Woodbury and Trent Northen. Porous Acrylate Copolymer Films and Uses Therefor (US 12/018,398) 2008

Book Chapters:

Northen, Trent, R. The small molecule dimension: mass spectrometry based metabolomics, enzyme assays, and imaging. Handbook of Molecular Microbial Ecology: Metagenomics and Complementary Approaches. Wiley Press. Frans J. de Bruijin Editor

Northen, Trent, R. Harnessing Microbial Metabolism for Biofuels and Biomaterials. Fundamentals of Materials for Energy and Environmental Sustainability. Cambridge Press. David Ginley & David Cahen Editors.